Lack of AKT in adipocytes causes severe lipodystrophy

Lack of AKT in adipocytes causes severe lipodystrophy

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Objective: Adipose depot mass is tightly regulated to maintain energy homeostasis.AKT is a critical kinase in the insulin-signaling cascade that is required for the process of adipogenesis in vitro.However, the role of AKT in the maintenance and/or function of Coffee mature adipocytes in vivo had not been examined.Methods: To study this, we deleted Akt1 and Akt2 in adipocytes of mice using the AdipoQ-Cre driver.Results: Strikingly, mice lacking adipocyte AKT were severely lipodystrophic, having dramatically reduced gonadal adipose and no discernible subcutaneous or brown adipose tissue.

As a result, these mice developed severe insulin resistance accompanied by fatty liver, hepatomegaly and with enlarged islets of Langerhans.Conclusions: These data reveal the critical role of adipocyte AKT and insulin signaling Cutting Saddle for maintaining adipose tissue mass.Author Video: Author Video Watch what authors say about their articles Keywords: Akt, Lipodystrophy, Insulin signaling, Insulin resistance.